Poster – Evaluation of a Next-Generation Sequencing Metagenomics Assay to Detect and Quantify DNA Viruses in Plasma from Transplant Patients

Jun 1, 2019

Enabling NGS-based metagenomics in the clinical virology laboratory

Poster Presentation given at the Clinical Virology Symposium 2019

Evaluation of a Next-Generation Sequencing Metagenomics Assay to Detect and Quantify DNA Viruses in Plasma from Transplant Patients

This poster was presented at the Clinical Virology Symposium on May 6th, 2019 by Dr. Soya S. Sam, a member of Dr. Angela Caliendo team from the Warren Alpert School of Medicine at Brown University.

Abstract:

“Viral infections are major causes of morbidity and mortality in solid organ and hematopoietic stem cell transplant patients Cytomegalovirus (CMV), Epstein–Barr virus (EBV) and BK virus (BKV) are among the most common infections after allogeneic transplantations and are individually tested using qPCR assays.

Metagenomics based on shotgun next-generation sequencing allows an unbiased approach for the detection of nearly all potential pathogens in a single assay. The objective of the study was to evaluate the performance characteristics of the Galillo™-Transplant assay by comparing with standard-of-care qPCR assays using viremic plasma from transplant patients.”

In this presentation you will learn:

What is NGS-based metagenomics (mNGS) is and how it can be applied to pathogen detection
How mNGS compares with and improves upon qPCR as a detection platform
What the mNGS workflow looks like when deployed in your laboratory
Why deploying mNGS into your laboratory makes sense
How Arc Bio has approached mNGS with its Galileo™ platform

Brown Poster

For research use only. Not for use in diagnostics or diagnostic procedures.

Do you have a Question about Galileo™

We’d love to hear from you! Do you have any questions about the Galileo™ Platform?

Workshop – Evaluation of the Galileo™ Pathogen Solution Next-Generation Sequencing Pipeline for the Detection and Quantitation of DNA Viruses in Immunocompromised Hosts

May 6, 2019

Evaluation of the Galileo Pathogen Solution Next-Generation Sequencing Pipeline for the Detection and Quantitation of DNA Viruses in Immunocompromised Hosts

Clinical Virology Symposium 2019 – Workshop

Part of a workshop presented at the Clinical Virology Symposium on May 6th, 2019 by Dr. Benjamin Pinsky, Associate Professor of Pathology and Medicine at Stanford Health Care and Stanford Children’s Health.

Dr. Pinsky outlines the current state of clinical virology testing for immunocompromised hosts and presents data from a single institution retrospective study of the Galileo™-Transplant NGS Pipeline for detection and quantitation of DNA viruses conducted at Stanford Health Care.

In this presentation you will learn:

Why deploying NGS-based metagenomics (mNGS) into your laboratory makes sense
How mNGS compares with and improves upon qPCR as a detection platform
How to validate mNGS-based assays in your laboratory
How mNGS identified additional viruses missed by conventional qPCR in over 50% of samples

Workshop Video (18:51 minutes):

Workshop Slide Deck (17 slides):

For research use only. Not for use in diagnostics or diagnostic procedures.

Do you have a question about Galileo™?

We’d love to hear from you!

Workshop – Enabling NGS-based metagenomics in the clinical virology laboratory

May 6, 2019

Enabling NGS-based metagenomics in the clinical virology laboratory

Clinical Virology Symposium 2019 – Full Workshop

This workshop was presented at the Clinical Virology Symposium on May 6th, 2019 by:

Dr. Benjamin Pinsky of Stanford Health Care and Stanford Children’s Clinic
Dr. Julianne Brown of Great Ormond Street Hospital for Children NHS Foundation Trust
Dr. Jesus Ching, Senior Vice President of R&D at Arc Bio.

The workshop examines the use of NGS-based metagenomics as a platform for pathogen detection in the clinical virology laboratory.

In these workshop presentations you will learn:

What is NGS-based metagenomics (mNGS) is and how it can be applied to pathogen detection
How mNGS compares with and improves upon qPCR as a detection platform

What the mNGS workflow looks like when deployed in your laboratory
Why deploying mNGS into your laboratory makes sense

How mNGS has been used to identify unexpected and novel pathogens related to viral encephalitis
How mNGS identified additional viruses missed by conventional qPCR in over 50% of samples

How to validate mNGS-based assays in your laboratory
How Arc Bio has approached mNGS with its Galileo™ platform

Dr. Benjamin Pinsky
Medical Director, Clinical Virology,
Stanford Health Care and Stanford Children’s Health
Evaluation of the Galileo™ Pathogen Solution Next- Generation Sequencing Pipeline for the Detection and Quantitation of DNA Viruses in Immunocompromised Hosts

Dr. Julianne Brown
Clinical Scientist,
Great Ormond Street Hospital for Children NHS Foundation Trust
How can we use metagenomics for the diagnosis and management of patients?

Dr. Jesus Ching
Senior VP R&D, Arc Bio LLC
Introduction to the Galileo™ Pathogen Solution platform

Workshop Video (1 hour 21 minutes):

Dr. Jesus Ching’s Slides (20 slides):

Dr. Ben Pinsky’s Slides (17 slides):

Dr. Julianne Brown’s Slides (21 slides):

For research use only. Not for use in diagnostics or diagnostic procedures.

Do you have a question about Galileo™?

We’d love to hear from you!

Workshop – How can we use metagenomics for the diagnosis and management of patients?

May 6, 2019

How can we use metagenomics for the diagnosis and management of patients?

Clinical Virology Symposium 2019 – Workshop

Part of a workshop presented at the Clinical Virology Symposium on May 6th, 2019 by Dr. Julianne Brown, Clinical Scientist at Great Ormond Street Hospital for Children NHS Foundation Trust in London.

Dr. Brown discusses the challenges and benefits of using NGS-based metagenomics in the diagnosis and characterization of viral encephalitis cases and it’s a comparison to the use of qPCR as a diagnostics tool.

In this presentation you will learn:

What is NGS-based metagenomics (mNGS) is and how it can be applied to pathogen detection
What the mNGS workflow looks like when deployed in your laboratory
Why deploying mNGS into your laboratory makes sense
How mNGS compares with and improves upon qPCR as a detection platform
How mNGS has been used to identify unexpected and novel pathogens related to viral encephalitis

Workshop Video (25:35 minutes):

Workshop Slide Deck (21 slides):

For research use only. Not for use in diagnostics or diagnostic procedures.

Do you have a question about Galileo™?

We’d love to hear from you!

Poster – Performance of an NGS-based metagenomics assay to simultaneously detect and quantify multiple DNA viruses

May 6, 2019

Enabling NGS-based metagenomics in the clinical virology laboratory

Poster Presentation given at the Clinical Virology Symposium 2019

Learn more about Galileo™

Performance of an NGS-based metagenomics assay to simultaneously detect and quantify multiple DNA viruses

This poster was presented at the Clinical Virology Symposium on May 6th, 2019 by Dr. Julianne Brown, Clinical Scientist in the Virology Department at Great Ormond Street Hospital for Children NHS Foundation Trust in London.

Abstract:

“Viral infections in solid organ and bone marrow transplant recipients can cause outcomes ranging from severe illness to transplant failure and even death. Current diagnostic assays use PCR to measure qualitative and quantitative presence of a target virus enabling clinical assessment of progression and the efficacy of treatment, however, these require multiple reactions and fail to detect non-targeted co-infections, which are common in immunocompromised patients.

Metagenomic next-generation sequencing (mNGS) has the potential to determine the presence and abundance of transplant-related viruses, as well as identify co-infections, in an unbiased manner.”

In this presentation you will learn:

What is NGS-based metagenomics (mNGS) is and how it can be applied to pathogen detection
How mNGS compares with and improves upon qPCR as a detection platform
What the mNGS workflow looks like when deployed in your laboratory
Why deploying mNGS into your laboratory makes sense

GOSH poster

For research use only. Not for use in diagnostics or diagnostic procedures.

Do you have a Question about Galileo™

We’d love to hear from you! Do you have any questions about the Galileo™ Platform?